Statins work to stop the production of cholesterol in the liver by blocking an enzyme called HMG-CoA reductase.

FORBES: Magazine Article

Blocking HMG CoA reductase not only prevents the formation of cholesterol, but also the creation of Rho kinase.

FORBES: The Statin Showdown

The body reacts by trying to turn HMG co-reductase back on, counteracting some of the effectiveness of the statins.

FORBES: The Heart Drug Junkyard

The statins work by blocking an enzyme called HMG co-reductase, explains Daniel Rader, a cholesterol expert at the University of Pennsylvania.

FORBES: Magazine Article

They have a change in a gene called Methylenetetrahydofolate Reductase, which alters the way folic acid is processed in the body.

BBC: Folic acid 'cuts cleft palate risk'