abstract:The malonic ester synthesis is a chemical reaction where diethyl malonate or another ester of malonic acid is alkylated at the carbon alpha (directly adjacent) to both carbonyl groups, and then converted to a substituted acetic acid. The major drawback of malonic ester synthesis is that the alkylation stage can also produce dialkylated structures.
In the firstpart, chemicalsynthesis, including by acraldehyde, malonicester, ami no lactone and others were discussedandsynthesis by hydantoin was emphasized.