The company looks poised to make a significant breakthrough in China.

该公司看上去稳将在中国实现一次重大突破。

《柯林斯英汉双解大词典》

The Bonn talks were not expected to make a significant breakthrough.

大家本来也没希望波恩会谈能取得重大突破。

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For me, the point here is that it takes a significant time commitment to make any sort of breakthrough when working on ambiguous questions.

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"This is a significant breakthrough on the road to health care reform, one that will make the difference in the lives of many older Americans, " Obama said at the White House.

CNN: Obama praises drug industry deal to cut costs for elderly