Because polycythemia may require dose reductions or discontinuation of therapy, hematocrit should be obtained at baseline, 3 to 6 months after initiation of therapy, and annually thereafter.

If you spend more that your paycheck by 10% by charging things on a credit card it can have very negative consequences in the long term by creating a growing debt balance with high interest.

This is usually a much stronger requirement than quadratic integrability.