Interaction trap, also termed two hybrid system, is a novel genetic method to identify proteins that interact with a known protein.

Interaction trap, also termed two hybrid system, is a novel genetic method to identify proteins that interact with a known protein. The principle, strategy and application of the method are reviewed.

These results should be carefully examined before coming to any conclusion, as many traps await the similarity seeker: paralogues, multidomain proteins, pseudogenes, etc.