• That can happen but that's abnormal, but changes in maybe the chemistry of the backbone that holds the nucleotides together.

    这可能发生的,但属于非正常的变化,而是改变诸如维持核苷酸序列的,主链的化学结构

    耶鲁公开课 - 生物医学工程探索课程节选

  • This material will be necessary to do the listening exercises for the course, which is sort of the backbone of the course.

    做听力练习时我们必须使用这些材料,听力训练是课程的核心内容

    耶鲁公开课 - 聆听音乐课程节选

  • One thing to notice is this part of the double helix that we'll call the backbone.

    要注意的是,这两股构成双螺旋的链我们称之为主链

    耶鲁公开课 - 生物医学工程探索课程节选

  • He is independent in a way that nobody who was not a king or an aristocrat in the past has ever been -- a new kind of man, the backbone of the polis as it emerges.

    他是如此的独立以至于,前无古人后无来者,一个全新的人,它不断地发展并成为城邦制的脊梁

    耶鲁公开课 - 古希腊历史简介课程节选

  • So what's going to form the backbone is this continual link, phosphate to sugar, phosphate to sugar, phosphate to sugar, all linked together to form one long, long molecule.

    主链是由这样重复的连接构成的,从磷酸到戊糖,周而复始,所有这些连接起来构成一个长链分子

    耶鲁公开课 - 生物医学工程探索课程节选

  • The backbone is what?

    主链是什么

    耶鲁公开课 - 生物医学工程探索课程节选

  • This represents the upright struts on a ladder that I showed you before, it represents this backbone that's shown by - that's formed by polymerizing the pentose's together through phosphate's always going 5' to 3', 5' to 3'.

    线条代表梯子,上下的支柱 之前给你们演示过,代表由多聚戊糖分子,通过磷酸基从5'端向3'端方向,连接起来的主链

    耶鲁公开课 - 生物医学工程探索课程节选

  • It's the phosphate and the pentose that make up the backbone - that make up the upright struts of the ladder and it's the bases that make up the connecting struts, so the bases are the colors.

    磷酸基和戊糖,共同构成了主链,主链又构成了梯子上下的支柱,而碱基,则构成连接支柱的梯阶,碱基是用各种颜色表示的

    耶鲁公开课 - 生物医学工程探索课程节选

  • The backbone's on the outside of the molecule like the upright struts of a ladder on the outside of a ladder.

    主链位于DNA分子结构外侧,像梯子两侧上下的支柱,记住是梯子外侧

    耶鲁公开课 - 生物医学工程探索课程节选

  • In some cases that backbone gets methylated and those regions of the DNA that are methylated get treated differently by the cell than unmethylated regions.

    一些情况下,主链会甲基化,该甲基化区域的DNA,和未甲基化区域的DNA,会被细胞区别对待

    耶鲁公开课 - 生物医学工程探索课程节选

  • Every unit in the backbone of this ladder has the same sugar unit, the same pentose; it's either RNA or DNA and has ribose or deoxyribose, so you don't need to describe the whole thing.

    主链的每个单位,都由相同的糖单位构成,同样的戊糖,RNA里是核糖,DNA里是脱氧核糖,所以你不需要所有细节都描述

    耶鲁公开课 - 生物医学工程探索课程节选

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