The individual variation may be caused by many factors, such as genetics, environment, disease stage and diet, etc, among which genetic polymorphism is a common and uncontrollable factor.
这种差异可能是由遗传、环境、疾病状态或饮食结构等诸多因素引起的。其中基因(遗传)多态性是导致药物代谢个体差异的较为常见且不可调控的因素。
So gender, age and BMI may have no significant effect on genetic polymorphism of CYP2C19.
可以初步推断，性别、年龄和体重指数可能不是CYP2C19遗传多态性的主要影响因素。
In the present article, genetic polymorphism of CYP2D6 and its clinical implications were reviewed.
本文综述了CYP2D6在遗传多态性方面的研究进展及其临床意义。
Aim to assess the effect of gender on genetic polymorphism of cytochrome CYP2C19 in Chinese population.
目的考察性别对中国汉族人群细胞色素氧化酶cyp2c19遗传多态性的影响。
Research on genetic polymorphism of CYP450s is significant to drug design, screening, evaluation and optimization.
研究CYP450对新药设计、筛选、评价及优化有重要意义。
Objective To obtain the genetic polymorphism data of two STR loci D2S1399 and D5S2500 in Eastern Chinese Han population.
目的研究D2S1399和D5S2500基因座在中国华东地区汉族群体遗传多态性。
In this article, the relation of CYP19 genetic polymorphism and breast cancer susceptivity and its therapy are reviewed.
现综述CYP19多态性与乳腺癌易感性及其治疗相关性。
Objective To evaluate the genetic polymorphism of Serratia marcescens by randomly amplified polymorphic DNA (RAPD) method.
目的应用随机扩增DNA多态性（RAPD）技术对医院感染的粘质沙雷菌进行基因分型。
Tumour susceptibility is associated with genetic polymorphism of xenobiotics metabolism enzyme and chromosomal aberrations et al.
肿瘤易感性与异源物代谢酶遗传多态性和染色体畸变等相关。
Population genetic polymorphism analysis showed that the polymorphism information content (PIC) of the 5 sheep breeds was moderate.
群体遗传多态性分析表明，5个绵羊品种的多态信息含量均为中度多态；
For families without inversions, it is easier and more cost-effective to undertake linkage analysis of genetic polymorphism based on PCR.
对于无倒位的家系，利用基因多态性进行遗传连锁分析较为有效可行。
Objective To investigate the genetic polymorphism of sartan drug metabolic enzyme CYP2C9 and angiotensin AT1 receptor in hypertensive patients.
目的本研究旨在观察沙坦类药物代谢酶CYP2C9和反应受体AT1的遗传多态性在高血压患者中的分布特征。
Objective: To evaluate the relationship between genetic polymorphism of HLA-DR and insulin-dependent diabetes mellitus (IDDM) in Chinese population.
目的：综合评价中国人群HLA鄄DR基因多态性与胰岛素依赖性糖尿病穴IDDM雪的关联性。
Objective To obtain the distribution of genetic polymorphism of X chromosome specific short tandem repeat loci DXS16 in Han groups of Henan province.
目的：获得X染色体短串联重复序列DXS16遗传多态性在河南汉族人群中的分布状况。
In this review, we summarize the function and signal transduction pathways of TLR4 and the correlation between genetic polymorphism of TLR4 and sepsis.
现就TLR4的功能、信号转导通路及其基因多态性与脓毒症易感性的相关关系作一综述。
The secondary objective was to determine whether the magnitude of the pharmacokinetic interaction was influenced by P-glycoprotein genetic polymorphism.
其次，分析药物药代动力学的改变程度是否与P -糖蛋白的遗传多态性有关。
OBJECTIVE To investigate the genetic polymorphism of dihydropyrimidine dehydrogenase gene (DPYD) in the patients with gestational trophoblastic disease.
目的探索妊娠滋养细胞疾病患者的二氢嘧啶脱氢酶基因(DPYD)多态性。
Objective to study the possible relationship between genetic polymorphism of N-acetyltransferase 2 (NAT2) and susceptibility to hepatocellular carcinoma.
目的探讨n -乙酰基转移酶(NAT2)基因多态性与肝癌易感性的关系。
The genetic polymorphism of drug metabolizing enzyme, transporter and target greatly influence the individual difference of drug efficiency and toxicity.
药物代谢酶、转运体及药物作用靶点存在着的基因多态性与药物疗效和毒性的个体差异有很大关系。
Objective To investigate the genetic polymorphism of microsatellite in the exon 5 of MICA gene and the intron 1 of MICB gene in Guangdong Han population.
目的调查广东地区汉族人群MICA基因第5外显子和MICB基因第1内含子微卫星多态性分布。
Objective In order to examine the relationship between glutathiones transferase M1, T1(GSTM1, GSTT1)genetic polymorphism and susceptibility to gastric cancer.
目的探讨谷胱甘肽转硫酶M1（GSTM1）、T1（GSTT1）基因多态性与胃癌遗传易感性的关系。
Objective to investigate the genetic polymorphism of HLA-DRB1 allele in Chongqing population and to analyze the characteristic of the allele frequency distribution.
目的了解重庆地区人群HLADRB1基因多态性，分析人群HLADRB1基因频率分布特征。
Single Nucleotide polymorphism (SNP) site is the main content of genetic polymorphism study, which includes detection of gene type and research on function and activity.
SNP位点是目前基因多态性研究的主要内容，包括检测分型和功能活性研究两个层次，已经建立了高度自动化和高通量的SNP检测分型技术。
Quail lines selected for high and low stress in Department of Poultry Science, LSU, USA were fingerprinted by RAPD analysis of genomic DNA to evaluate genetic polymorphism.
本研究对美国路易斯安那州立大学家禽系选育的高应激和低应激两个品系鹌鹑进行RAPD分析，评定其遗传多态性。
The objective of this study is to investigate the relationship between genetic polymorphism of GSTT1 and inherent susceptibility to lung cancer in Han population in Sichuan, China.
本研究的目的是探讨GSTT1基因多态性与中国四川汉族人群肺癌遗传易感性的关系。
In the Present article, the characterization, substrates, probe drugs, factors affecting its activity, genetic polymorphism and the relation between CYP2D6 and several diseases were reviewed.
本文综述了CYP2D6的结构特点，底物，探针药物，影响其活性的因素，基因多态性以及它与疾病的关系。
Objective To analyze the association of N-acetyltransferase 1 (NAT1) genetic polymorphism with the susceptibility of elderly gastric adenocarcinoma (GAC) and colorectal adenocarcinoma (CRAC).
目的探讨N 乙酰化转移酶1（NAT1）基因多态性与老年人胃肠腺癌易感性的关系。
Objective To investigate the genetic polymorphism of HLA-B locus in Guangdong Han population and compare the characteristic of the allele frequency distribution with that in other populations.
目的调查广东汉族人群HLA-B位点基因多态性，比较不同人群HLA-B等位基因频率分布特征。
Objective to explore the effects of interaction between environmental exposure factors and genetic polymorphism in toxicant metabolizing enzymes on risk of occupational chronic benzene poisoning.
目的研究环境暴露因素与毒物代谢酶基因多态性对发生慢性苯中毒危险性的影响。
Conclusion: Genetic polymorphism of the HSF2 gene might not be the susceptible factors of NIHL.
结论：HSF2基因多态性可能不是噪声性听力损失的遗传易感性因素。
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