Overexpression of procollagen gene can cause the extraordinary increase of collagen's synthesis and therefore lead to the keloid and hypertrophic scar.
增殖性瘢痕组织中胶原蛋白的合成显著增加从而导致胶原的过度沉积。
On the other hand, sometimes they grow thick, tough, and corded, forming a hypertrophic scar or keloid, and may cause severe pruritus.
另一方面，也可增厚，变粗糙和如索状，形成肥厚性疤痕或瘢痕疙瘩，引起重度瘙痒。
Hypertrophic scar and keloid often occur in clinical practice, but the mechanisms of them are still not clear enough.
创面的异常修复导致增生性瘢痕和瘢痕疙瘩的形成在临床工作中非常常见，其发病机理仍不完全清楚。
Objective to explore the effect of connective tissue growth factor on the pathogenesis of hypertrophic scar and keloid tissue.
目的探讨结缔组织生长因子在增生性瘢痕和瘢痕疙瘩发病机制中的作用。
Objective to explore the correlation between the expression of connective tissue growth factor and the formation of hypertrophic scar and keloid tissues.
目的探讨结缔组织生长因子的表达与病理性瘢痕形成的相关性。
Conclusion the recombinant adenovirus vector carrying human TRADD gene was successfully constructed. It can be used for detecting the effects of TRADD on fibroblasts of hypertrophic scar and keloid.
结论构建成功的含有TRADD基因片段的重组腺病毒，可用于转染人成纤维细胞，用于检测TRADD对病理性瘢痕成纤维细胞的影响。
Conclusion the recombinant adenovirus vector carrying human TRADD gene was successfully constructed. It can be used for detecting the effects of TRADD on fibroblasts of hypertrophic scar and keloid.
结论构建成功的含有TRADD基因片段的重组腺病毒，可用于转染人成纤维细胞，用于检测TRADD对病理性瘢痕成纤维细胞的影响。
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