There has been a lot of controversy regarding these drugs and that has made many dermatologists cautious about prescribing isotretinoin (Accutane).
关于这些药物存在很多的争论，这导致了很多皮肤科医生开异维甲酸(青春痘特效药)的处方时非常小心。
It's known that retinoids can damage the developing fetal nervous system, which is why Accutane cannot be given to pregnant women.
众所周知类视黄醇嫩能够损伤正在发育的胎儿的神经系统，因此孕妇不能使用。
Based on evidence from previous research, they note, Accutane might alter the regulation of brain chemicals like dopamine and serotonin, which are implicated in depression.
基于以前研究所得到的证据，他们提到，Accutane可能改变人脑中对化学物质如多巴胺和5 -羟色胺的调节，这可能与抑郁症有关。
Depression is a complex disorder and, therefore, difficult to pin down to a single cause. For example, Accutane users often have severe acne, which itself may lead to depression.
抑郁症是一种复杂的病症，因此很难把它的发生归结于单一的因素。比如异维甲酸使用者常常患有严重的痤疮，这种病本身就可能导致抑郁症。
For more severe cases, doctors may prescribe antibiotics to curb bacterial growth or large doses of vitamin a derivatives, such as Accutane, which unplug pits and can help prevent scarring.
对于病情严重的患者，医生也可以使用抗生素来抑制细菌生长，或者用大剂量的维生素a衍生物，像Accutane来去除丘疹，并防止在皮肤上留下疤痕。
For more severe cases, doctors may prescribe antibiotics to curb bacterial growth or large doses of vitamin a derivatives, such as Accutane, which unplug pits and can help prevent scarring.
对于病情严重的患者，医生也可以使用抗生素来抑制细菌生长，或者用大剂量的维生素a衍生物，像Accutane来去除丘疹，并防止在皮肤上留下疤痕。
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