The New York Daily News reported Friday that Gotti is suffering from throat cancer.
The Vatican bank's chief, Ettore Gotti Tedeschi, is credited with a hard line on compliance.
In the early 1990s, she brought down John Gotti, the head of the Gambino crime syndicate.
The Vatican Bank has been headed by Mr Gotti Tedeschi, 62, a trained economist, since 2009.
And the main issue was that Castellano suspected the Gotti crew of engaging in heroin trafficking.
She led the prosecution of Gotti, who was convicted in 1992 of murder, racketeering and other offenses.
In 2010 Italian police launched an investigation against Mr Gotti Tedeschi as part of a money-laundering inquiry.
The bank's board of directors unanimously passed a no-confidence vote in Mr Gotti Tedeschi, a statement said.
In real life, as the hard-nosed U.S. District Attorney, she put away bad guys like mobster John Gotti.
By the time Gotti finished serving a two-year prison sentence for the McBratney slaying, Carlo Gambino had died.
Federal prosecutors identified Gotti as head of the New York-based Gambino crime family.
After court, Kaplan attorney Sadow said transporting the younger Gotti was a prosecution stunt designed to prejudice the jury.
Neither Smith nor Bureau of Prisons spokeswoman Tracy Billingsley would disclose the nature of Gotti's illness or course of treatment.
Mr Gotti Tedeschi, who is an expert on financial ethics, has been in charge of the bank for a year.
Atlantic Records Vice President Cara Donatto threw some weight behind the MTV reality show "Gotti's Way, " which she once produced.
Operating out of the Ravenite Social Club in Manhattan and the Bergen club in Queens, Gotti quickly consolidated his power.
McLain was indicted in 1998 along with John A. (Junior) Gotti in a phone-card scam, but the charges were dropped in 1999.
The director of the Vatican Bank, Ettore Gotti Tedeschi, has been removed from his post for dereliction of duty, the Vatican says.
At the time, Gotti was a rising star within the family, and unbeknownst to Castellano, he was also a potentially deadly rival.
Jerry Capeci of New York's John Jay College of Criminal Justice, who has written several books about organized crime, recalls Gotti's aura.
Within weeks, Gotti, with the consent of the various crew captains, or capos, of the Gambino family, was selected the new godfather.
One son, John A. Gotti, is also behind bars, serving 77 months.
On December 16, 1985, Gotti and a small band of Gambino family co-conspirators waited for Castellano outside the Sparks Steak House in Manhattan.
When Mr Gotti Tedeschi was placed under investigation in 2010, the Vatican said it was "perplexed and astonished", and expressed full confidence in him.
His son, John A. Gotti, last year began serving a six-year federal sentence for racketeering, bribery, and tax evasion in an upstate New York prison.
Mr Gotti Tedeschi's refusal to do that heralded their later rows.
Castel has adjudicated cases involving accused mobsters (John Gotti, Jr.) and cases involving rappers (Kanye West) but never one with a party from the late Cretaceous.
Gotti, who turns 60 next month, was transferred from the federal penitentiary in Marion, Illinois, to the prison hospital on September 13, said hospital spokesman Dianne Smith.
Gotti, who is serving a life sentence for murder and racketeering, is being treated at the U.S. Medical Center for Federal Prisoners in Springfield, Missouri, prison officials said Friday.
She also won high-profile convictions in the 1993 World Trade Center bombing and the 1998 terrorist attacks on two U.S. embassies in Africa, and put crime boss John Gotti away.
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