• The gene mutation ends up causing lower-than-normal production of a protein called ApoCIII.

    CNN: Gene mutation protects against milk shakes and other fatty fare

  • By contrast, Japanese patients with another gene mutation were found to have high HDL but no evidence of benefit.

    FORBES: Magazine Article

  • His tumor had a gene mutation being targeted by a new cancer vaccine being tested by Duke neurosurgeon John Sampson.

    FORBES: Magazine Article

  • Hoffman at UC, San Diego in 2001 pinpointed the gene mutation that causes Muckle-Wells and the inherited overreaction to drafts.

    FORBES: The Ultimate Targeted Therapy

  • Bristol-Myers and ImClone could lose a significant chunk of sales as doctors stop using it in patients with the gene mutation.

    FORBES: ImClone's Gene Test Battle

  • But Italian researchers 27 years ago discovered one family whose HDL levels were lower than 15 because of a gene mutation.

    FORBES: Magazine Article

  • The German researchers examined the body weights and DNA of 181 relatives of 25 extremely obese patients who carried the gene mutation.

    BBC: NEWS | Health | Faulty gene link to obesity risk

  • The best Elan trial results unexpectedly came in the subset of about 35% of patients who lack a gene mutation called APOE4.

    FORBES: Magazine Article

  • The rarer oculocutaneous albinism type 3 is caused by a gene mutation on chromosome 9 and has been primarily identified in black South Africans.

    CNN: Albinism

  • It did not reach its main efficacy goal in a second-trial trial, but did help a subset of patients without a certain gene mutation.

    FORBES: Elan Defends Alzheimer's Science

  • Just this week, Italian researchers pinpointed another gene mutation present in about 10% of colon cancer patients that appears to render Erbitux and Vectibix ineffective.

    FORBES: Genetic Testing

  • But there were chemotherapy options, notably a relatively new drug called Tarceva, which targets a gene mutation commonly found in lung cancers of female non-smokers.

    NEWYORKER: Letting Go

  • Scientists from the Centre for Research on Women's Health in Toronto led the study which looked at women with the BRCA1 and BRCA2 gene mutation.

    BBC: Tamoxifen 'cuts genetic cancer risk'

  • It shrunk tumors in 10 of 18 lung cancer patients with a particular gene mutation that occurs in 5% of lung cancers, often in younger nonsmokers.

    FORBES: American Society of Clinical Oncology

  • Novartis is in final trials of a drug that may help the one-third of acute myeloid leukemia cases with a gene mutation that turns on cell-growth signals.

    FORBES: Magazine Article

  • She developed an aggressive form of breast cancer at age of 31, and later learned she had a gene mutation that's been linked to breast and ovarian cancer.

    NPR: Senate OKs Bill Outlawing Genetic Discrimination

  • The medicine basically undid five years of lung deterioration for patients who took it, but will only work for those whose CF is caused by a specific gene mutation.

    FORBES: Personalized Medicine: A Discussion

  • Oculocutaneous albinism type 4, caused by a gene mutation on chromosome 5, is an uncommon form of the disorder generally presenting signs and symptoms similar to those of type 2.

    CNN: Albinism

  • The goal is to try to find the best place to intervene with a drug, rather than just going after whatever tumor gene mutation happened to be discovered most recently.

    FORBES: A New Way To Find Cancer Drugs

  • Late Tuesday afternoon, the companies presented mediocre trial results showing that bapineuzumab (b-mab for short) didn't work overall in an 18-month second stage trial but seemed to help a subset of patients who lack a certain gene mutation, APOE4.

    FORBES: Magazine Article

  • In the trial, which included 55 patients, tumors dramatically shrank in 9 of 16 very advanced patients with the gene mutation who got high doses--a better response rate than doctors have remembered seeing in a trial for advanced melanoma.

    FORBES: American Society of Clinical Oncology

  • But for the average breast cancer patient who has neither the BRCA1 or BRCA2 gene mutation nor a close relative with breast cancer (Jolie's mother, for example, died from ovarian cancer), the risk of a new breast cancer in the nonaffected breast is less than 1%.

    CNN: When removing breast is not the answer

  • The discovery of the FOXP2 brain gene, a mutation of which can cause language loss, was met with considerable excitement when it was announced over a decade ago.

    ECONOMIST: What makes some people learn language after language?

  • Oculocutaneous albinism type 1 is caused by a mutation in a gene on chromosome 11.

    CNN: Albinism

  • Oculocutaneous albinism type 2 is caused by a mutation in a gene on chromosome 15.

    CNN: Albinism

  • Apparently, a mutation in this gene or, more probably, in the control system that activates it gave rise to Volvox.

    ECONOMIST: How to become multicellular

  • Roche's drug, called PLX4032, targets a mutation in a gene called BRAF that appears to be an important growth driver in 60% of melanoma cases and is also found less frequently in many other cancers.

    FORBES: Magazine Article

  • The emerging data, much of it being released at a big meeting of cancer specialists this weekend in Chicago, reveal that Erbitux is utterly ineffective in about 40% of colon cancer patients whose tumors have a mutation in a gene called kras.

    FORBES: ImClone Gets Targeted

  • In 2002 gene researchers in the U.K. discovered that two-thirds of melanomas have a mutation in a growth-promoting gene inside skin cells called BRAF.

    FORBES: Targeting Melanoma

  • Herceptin is a breast cancer drug that was developed to treat tumors that have a specific mutation in the Her2 gene.

    FORBES: Why Personalized Medicine Is Bunk

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