Certain dietary supplements such as vitamin D and fish oil have proven benefits, but others like bitter orange and vitamin B5 lack evidence.

CNN: Half of Americans use supplements

The macerated bitter orange peel is the same fruit used in the other variants of Grand Marnier, but this time they employ a unique double distillation, whereas it is usually distilled just once.

FORBES: What Does An $800 Bottle Of Grand Marnier Taste Like?

Although the short cocktail menu showcases unusual drinks like the Nice Legs -- made with gin, Barolo Chinato (an Italian digestive), Gentian (a bitter root) and orange peel -- many patrons will order a classic like an Old-Fashioned (bourbon whiskey, sugar, Angostura bitters, club soda and lemon peel) or leave their choice in the hands of the bartender.

BBC: The best cocktail bar in the US

It is a bitter reversal for Tymoshenko since the Orange Revolution days, when she and her ally Viktor Yushchenko packed the streets of Ukraine in protest at a rigged election that went in favour of the pro-Russian Mr Yanukovych.

BBC: Yulia Tymoshenko, file pic from January 2010

But so bitter is the disappointment in the orange team, so strong the craving for stability which (at least visually) he represents and so deep the suspicion, rational or otherwise, of Ms Tymoshenko that even in western Ukraine some voters may back Mr Yanukovich in the second round.

ECONOMIST: Ukraine's presidential election