Is that a big problem?

这是个大问题吗？

youdao

That a big problem.

这一个大问题。

youdao

Road, also not crowded, not the automobile exhaust emissions, all with maglev instead of fuel combustion, thus "greenhouse effect" that a big problem also disappear.

道路上，也没有了拥挤，没有了汽车尾气的排放，全都用磁悬浮来代替燃料的燃烧，从而“温室效应”这一大难题也随之消失。

youdao

Christian in France expressed a different concern, saying: The big problem of the transgenic seeds is that they are the monopoly of big companies.

VOA: special.2010.05.18

That's a big problem and so can you protect these cells that you give to the recipient from attack by the recipient's immune system?

并且至关重要,那么你们想办法保护这些植入受体的细胞,使它们免受免疫系统的排异反应么

耶鲁公开课 - 生物医学工程探索课程节选

That's a big problem a lot, I think in group projects

我觉得这是很多团队项目当中的大问题，

怎么协调意见冲突 - SpeakingMax英语口语达人

He could then add that a big problem remains: Tens of millions of our fellow citizens lack affordable health insurance.

WSJ: Rove: Obama's Health-Care Opportunity

None so far has suggested that a big problem exists.

FORBES: Fear And Loathing Along The Hedge Rows

But the initial denial that there was a problem simply became denial that there was a big problem.

FORBES: When You Hear "There's No Problem," Brace Yourself