...瘤的化疗,是消化系统肿瘤化疗的传统药物之一,但耐药性的产生严重影响其疗效,目前认为核苷酸切除修复(nucleotide excision repair,NER)是铂类药物耐药的重要机制之一,因其导致耐药的主要机理为清除大规模铂类化舍物所致DNA螺旋扭曲.
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...关键词】 ERCC1 XPC 核苷酸剪切修复 局部晚期宫颈癌 新辅助化疗 [gap=2457]Key words: ERCC1; XPC; nucleotide excision repair; locally advanced cervical cancer; neoadjuvant chemotherapy ..
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DNA的稳定性依赖于DNA的修复能力，核苷酸的切除修复（nucleotide excision repair）是人类DNA的主要修复方式，此外还包括复制后修复、光修复。切除修复过程：
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而核酸切除修复途径(nucleotide excision repair, NER)是DNA交联损伤的主要修复途径,其中ERCC1是NER限速酶。研究显示ERCC1第118位密.
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Nucleotide excision repair NER 核苷酸切除修复
Nucleotide excision repair gene 核苷酸切除修复基因
Nucleotide Excision Repair in Eukrayotes 真核细胞中的核苷酸切除修复
Nucleotide excision repair proteins 核苷酸切除修复蛋白
nucleotide excision repair genes 核苷酸切除修复基因
nucleotide excision repair ERCC1 核苷酸切除修复ERCC
nucleotide excision repair pathway 核苷酸切除修复通路
以上来源于: WordNet
Plant could repair DNA damage induced by UV-B through many methods, mainly included light-repair, base excision repair, nucleotide excision repair and recombination repair etc.
植物可以通过多种途径来修复紫外诱导的DNA损伤，主要包括光修复、碱基切除修复、核苷酸切除修复和重组修复等。
AIM: To investigate the expression of nucleotide excision repair gene ERCC1 and its relationship with PAH (polycyclic aromatic hydrocarbons) -dna adducts in lung cancer tissues.
目的：探讨核苷酸切除修复基因ERCC1在肺癌中的表达及其与多环芳烃(PAH) - DNA加合物的关系。
We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways.
由于核苷酸切除修复、药物转运和药物代谢通路在铂金药物功能中的重要性，这篇综述重点总结了这些通路中的基因表达和非癌细胞DNA变异与铂金疗效的关系。
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