I looked at my wife in despair.

我绝望地看着妻子。

《柯林斯英汉双解大词典》

He gave up the struggle in despair.

他绝望地放弃了斗争。

《牛津词典》

In despair he let it alone.

在绝望中，他任其自生自灭。

youdao

Residents in the area are in despair.

VOA: standard.2009.10.03

They were wandering in the forests and he was in despair, having lost everything.

他们在森林里流浪,那勒陷入绝望,他失去了一切

耶鲁公开课 - 金融市场课程节选

Mind you, he ascribes to authorial intention the most amazingly outrageous things that other critics threw up their hands in despair about, but nevertheless it is for him always still an appeal to authorial intention.

他认为写作意图,十分重要,但是被其他批评家忽视了，但是写作意图,十分吸引他。

耶鲁公开课 - 文学理论导论课程节选

For some reason, however, he was in despair when he returned home that night.

NPR: Literature and Lullabies from the 'Axis of Evil'

Its force commander, an experienced Spaniard, has resigned in despair seven weeks after taking over.

ECONOMIST: Congo

We wanted to convey a message to poor and illiterate families in despair: searching for family?

FORBES: Uniting Refugees in an Unconventional Way: Lessons Learned