I'm pretty desk-bound, which is very frustrating.

我基本上一直伏案工作，这真让人郁闷。

《柯林斯英汉双解大词典》

I'm pretty desk bound, which is very frustrating.

每天坐办公桌让我十分苦恼。

youdao

Now, I'm not sure how positive and negative started to be interpreted as good and bad, but for logical people, it can be very frustrating trying to make reality fit into positives and negatives.

现在我不确定积极和消极如何一开始就被解释为好和坏，但是对于逻辑思维的人来说，用消极和积极去衡量现实太难了。

youdao

I'm struggling to come to terms with this pessimism and find it very frustrating.

BBC: Jeremy Guscott column