Maybe we want to change the way we look. Perhaps we feel that losing 10 or 15 pounds, and getting back in shape, would make a big difference.

可能我们想改变我们看问题的方式，也可能我们非常想要减掉10到15磅重量以重新拥有好身材。

youdao

Besides the evolutionary odds against such a drastic change happening, a big alteration in the shape of its active site might well render an enzyme and thus the virus ineffective.

ECONOMIST: Nanotechnology in biology

That is, big nominal shocks combined with changes in the strength of contracts and obligations could change the shape of the economy forever.

FORBES: NGDP in the Long Run and Economic Plasticity