The solution sometimes is mixed with other medications, such as a local anesthetic.

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They randomly assigned patients to get either vertebroplasty or a fake procedure in which patients were injected with local anesthetic but no cement.

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It requires a local anesthetic and I'd say mild sedation.

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Previous work at Queen's University found that prawns show prolonged rubbing when an antenna was treated with weak acetic acid but this rubbing was reduced by local anesthetic.

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They came up with a plan for anesthesia based on research studies including giving certain pain medications before the patient entered the operating room and using spinal anesthesia plus an injection of local anesthetic to block the main nerve to the knee.

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