Objective To establish long-term cultured antigen-specific T cell line and clones and to analyze their T cell receptor usage.

目的体外建立可长期培养的抗原特异性T细胞系及克隆，并分析其T细胞受体的使用情况。

youdao

T cell receptor (TCR)gene rearrangement is an important event in T cell ontogeny that enables T cells to specifically recognise antigens, and any dysregulation in this process may result in diseases.

细胞在成熟过程中通过T细胞表面受体基因重排，从而具有特异性识别抗原的能力，在这一过程中的任何失调都会导致疾病。

youdao

In clinical practice we noticed that the successful implantation and the severity of GVHD were associated with t cell ratio of graft to receptor after pretreatment.

临床发现植入是否成功及GVHD的严重程度与预处理后供受体t细胞比例有关。

youdao

So, it doesn't need to bind to a receptor on the surface of the cell in order to work because the molecule can actually enter the cell directly.

所以无需与细胞表面受体相结合来起效,因为这些分子能直接进入细胞

耶鲁公开课 - 生物医学工程探索课程节选

Immune cells recognize it, and they recognize it by a very special form of receptor-ligand interaction where the ligand is MHC1 with the foreign antigen and the receptor is a receptor called the T-cell receptor complex.

免疫细胞识别出染病细胞,通过一种特殊形式的,受体配体协作机制识别出来,其中的配体是同,外源抗原共同出现的MHC1,而这其中受体是T细胞受体复合体

耶鲁公开课 - 生物医学工程探索课程节选

Dr. Brentjens and a fellow co-author hold a patent on the engineered T-cell receptor.

WSJ: Gene Therapy Shows Promise as Cancer Treatment

Dr. Brentjens and a co-author hold a patent on the engineered T-cell receptor.

WSJ: Gene Therapy Shows Promise as Cancer Treatment