It is indeed misery if I stretch an empty hand to men and receive nothing; but it is hopelessness if I stretch a full hand and find none to receive.

假如我向人伸出空手而得不到东西，那当然是苦恼；但是假如我伸出一只满握的手，而发现没有人来接受，那才是绝望呢。

youdao

But I sensed all of that changing as I experienced both the hopelessness and the hopefulness that comes with this noble profession.

然而，当我亲身经历随着这一神圣职业而来的无望和希望，我感觉到自己内心的巨大变化。

youdao

Optimism is often dismissed as false hope. But there is also false hopelessness. Thats the attitude that says we cant defeat poverty and disease. We absolutely can.

乐观常被视为错误的希望。但是错误的无望也存在于世，那就是我们无法击败贫困和疾病的态度。但我们却能够做到。

youdao

On the other hand, I had an early facility with language, but it was my complete hopelessness with arithmetic that was the single dominant experience of my young life.

NPR: Living With an Inability to Do Math

For yet other participants, they might not leave the market but nonetheless have a sense of hopelessness and despair.

FORBES: Get Ready For A Correction

For all her life, Ruth had known nothing but this world the world of apartheid, with its miasmic atmosphere of helplessness and hopelessness.

NPR: One Boy's Heroism in the Face of AIDS