Major depression can profoundly alter social, family, and occupational functioning.

抑郁症可以极深地改变人的社会，家庭，职业机能。

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Any significant shift in that balance could profoundly alter the course of Japan's foreign policy.

ECONOMIST: Japan and Iraq: Hostage diplomacy | The

Allowing both workers and retirees to have health savings accounts would profoundly and fundamentally alter the dynamics of health care economics.

FORBES: Magazine Article

The economic and political aftershocks extending around the globe will profoundly shake and alter broad aspects of U.S. and international policy far into the future, and particularly those related to energy strategies.

FORBES: Aftershocks: Nuclear Energy Fallout From Japan