• "That non-coding RNA, well,what does it do? Well,it's not that it's going to make a protein."

    VOA: standard.2010.04.05

  • It's not the best form of food in that they're actually very poor in protein, and unfortunately very, very rich in cyanide.

    但木薯的根并不是最好的食物,因为它的蛋白质含量很少,而更不幸的是,它的氰化物含量非常,非常高。

    麻省理工公开课 - 化学原理课程节选

  • Insulin is a naturally occurring hormone, it's a protein hormone that circulates in all of our bodies and regulates glucose metabolism.

    胰岛素是人体自身产生的一种激素,它是一种蛋白质激素,遍布全身,并调节糖代谢

    耶鲁公开课 - 生物医学工程探索课程节选

  • A child's weight and levels of C-reactive protein are strongly related,"

    VOA: standard.2010.03.09

  • The reason it is so exciting that it's a protein, and it's a protein, this is the structure here, it's a ribbon structure so you can kind of see what it looks like, it's made up of all natural amino acids.

    它这么让人激动的原因是因为它是一个蛋白质,这里的这个结构,这是个带状机构,你可以看到它的样子,它全部是由氨基酸组成的。

    麻省理工公开课 - 化学原理课程节选

  • The macro nutrients are the big constituents of food, that's protein, carbohydrate, and fat.

    大量营养素是食物重要组成来源,即蛋白质,碳水化合物和脂肪

    耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

  • What a kinase enzyme does is that it recognizes this protein, and for example, the tyrosine that's on the protein.

    激酶能够识别这类蛋白,例如,包含酪氨酸的蛋白

    耶鲁公开课 - 生物医学工程探索课程节选

  • If you could introduce that gene you'd make the chemical, in this case it's a protein called vascular endothelial growth factor.

    通过导入一种生成特殊化学物质的基因,这种疗法中指的是一种蛋白,叫做血管内皮生长因子

    耶鲁公开课 - 生物医学工程探索课程节选

  • For some of you that haven't I'll just say that it's a protein, it's 238 amino acids, which means that it's about 1,000, actually more than 1,000 atoms in size, and this protein is fluorescent.

    对于那些没听说过的人,我要说它是一种蛋白质,它有238个氨基酸,也就意味着它有约1000个,实际上是超过1000个原子,这种蛋白质是有萤光的。

    麻省理工公开课 - 化学原理课程节选

  • And it's neat to see the glowing jellyfish and think about the fluorescent protein that's in them.

    你可以看到整齐的水母,而且考虑它里面的蛋白质。

    麻省理工公开课 - 化学原理课程节选

  • They're making that because you need this protein insulin, it's a hormone, and it's important for sugar metabolism in your body.

    它们产生胰岛素蛋白是因为你需要它,胰岛素是一种激素,它在糖代谢中起着非常重要的作用

    耶鲁公开课 - 生物医学工程探索课程节选

  • Essentially, what they are is it's a protein that spans the membrane of a cell.

    本质上来说,它是一个横跨细胞膜的蛋白质。

    麻省理工公开课 - 化学原理课程节选

  • You get cystic fibrosis because one protein that's made by your lung epithelium is not expressed properly.

    得囊胞性纤维症的病因是,肺上皮细胞产生的一种蛋白,表达不正常

    耶鲁公开课 - 生物医学工程探索课程节选

  • In fact, for insulin, it's not the final version of the protein that comes out of translation.

    事实上,就胰岛素而言,翻译完成后的形式,还不是蛋白质的最终形式

    耶鲁公开课 - 生物医学工程探索课程节选

  • Well, insulin is a protein, it's produced by cells in the pancreas, it circulates in your blood.

    胰岛素是一种蛋白质,由胰腺细胞分泌,随着血液不断在体内循环

    耶鲁公开课 - 生物医学工程探索课程节选

  • An alternate way is to go to the cell that's making the protein that you want.

    另一种方法是,找到制造你想要的蛋白质的细胞

    耶鲁公开课 - 生物医学工程探索课程节选

  • Then, your muscle cells would start producing Hepatitis B surface antigen and your immune system recognizing that's a foreign protein would start responding to it.

    于是,肌肉细胞将会,开始制造乙肝表面抗原,然后免疫系统就会识别出,那是外来蛋白质并且产生免疫应答

    耶鲁公开课 - 生物医学工程探索课程节选

  • So if it's not a cell that's going through division you can't use a retrovirus to express the protein.

    如果细胞不在分裂阶段,你就不能用逆转录病毒来表达某个蛋白

    耶鲁公开课 - 生物医学工程探索课程节选

  • You could imagine a protein that's existing inside a cell at some level of abundance.

    想像一下,在细胞中有一种大量存在的蛋白

    耶鲁公开课 - 生物医学工程探索课程节选

  • It's a protein that's produced by other cells in the body and when it's enriched in a certain area it stimulates more production of red blood cells.

    这种蛋白由体内的另一种细胞生成,而当其在某处富集时,就会刺激红细胞生成

    耶鲁公开课 - 生物医学工程探索课程节选

  • Often the state of a protein depends on whether it's phosphorylated or not.

    蛋白的状态通常取决于,它们是否被磷酸化

    耶鲁公开课 - 生物医学工程探索课程节选

  • That's because every three base pairs describes an amino acid in a protein.

    那是因为每三个碱基对,对应一个蛋白质中的一个氨基酸

    耶鲁公开课 - 生物医学工程探索课程节选

  • The one that's on the top here is called ligand-gated ion channel and an ion channel is a protein that sits in the surface of a cell.

    最上面的这个叫作配体门控离子通道,离子通道是一类位于细胞表面的蛋白

    耶鲁公开课 - 生物医学工程探索课程节选

  • But that's not all, that protein insulin is made in the form of a long polypeptide that not - that's not always the final version of the protein.

    但这还没完,这个胰岛素蛋白刚翻译完成时,还是一段长多肽的形式,还不是蛋白质的最终形式

    耶鲁公开课 - 生物医学工程探索课程节选

  • So, a protein that has tyrosine and it has tyrosine in a position such that it's on the outside of the protein and accessible to chemical reaction can be phosphorylated.

    所以,一种蛋白质中含有酪氨酸,并且该酪氨酸位于,像蛋白质的外侧这样的位置,这样才能够发生磷酸化反应

    耶鲁公开课 - 生物医学工程探索课程节选

  • For now, just picture it in this simple way as a molecule, usually a protein, that's embedded in the cell membrane and many receptors have a part of them that is extracellular.

    现在,我只把这种分子图示出来,受体通常是一种蛋白质,它们镶嵌在细胞膜上,很多受体还有部分结构露在细胞外

    耶鲁公开课 - 生物医学工程探索课程节选

  • I'll use that one as the example because it's a familiar one to most people and you know that the protein insulin is made only in your pancreas and certain cells of the pancreas.

    我把它作为例子,是因为大多数人都很熟悉它,胰岛素只在胰腺中进行合成,某些胰腺细胞能够合成胰岛素

    耶鲁公开课 - 生物医学工程探索课程节选

  • These are two examples I just gave you of introducing genes that affect the life of a cell, either by making it express a protein that it's not making properly that's important to its life, or by intentionally killing a cell by having it express a fatal gene.

    刚才我所举两个例子,都只是影响单一细胞生命过程的,无论是使无法正常表达的重要蛋白,正常表达也好,或是有意地,导入致命的基因杀死细胞也好

    耶鲁公开课 - 生物医学工程探索课程节选

  • DNA goes to RNA, goes to protein, that's it, and that is the way it happens in simple organisms like bacteria.

    NA转录成RNA接着翻译成蛋白质,仅此而已,而这仅是细菌那样的简单有机体中的机制

    耶鲁公开课 - 生物医学工程探索课程节选

  • Those regions that are not are spliced out during RNA processing to form the mRNA transcript that's used to make the protein.

    而这些与生成胰岛素无关的区域,在RNA剪接过程中就被剔除,从而生成转录蛋白质的mRNA

    耶鲁公开课 - 生物医学工程探索课程节选

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