But for people who have a difficult time controlling their movements, this little navigational issue can be a really big problem.

VOA: special.2011.04.18

A big problem with this is a lot of Freudian theory is claimed to be validated in the course of psychoanalysis.

这里存在的一个大问题便是,精神分析理论中的很多内容,被认为是能够在精神分析的过程中,得到证实的。

耶鲁公开课 - 心理学导论课程节选

I had an injury as well, so I couldn't stand. That was my big problem.

我受过伤，所以我不能站着。这是我最大的问题。

记忆犹新的作品 - SpeakingMax英语口语达人

"Especially with the honor killings in the eastern parts. The safety of girls still remains a big problem.

VOA: special.2010.06.24

That's a big problem and so can you protect these cells that you give to the recipient from attack by the recipient's immune system?

并且至关重要,那么你们想办法保护这些植入受体的细胞,使它们免受免疫系统的排异反应么

耶鲁公开课 - 生物医学工程探索课程节选

It's also an escape. A big problem we have in the neighborhood is obviously gangs,and family dynamics.

VOA: special.2010.11.04

But,there was a big problem, that for all of his failings,human failings, and there were indeed many, and his intellectual limitations which were daunting, he was a man of faith and loyalty to his principles, for better or for worse,in this context.

但是他的弱点,人性的弱点,是个大问题,而且他的弱点确实很多,还有他的智力界限也令人沮丧,他是个固执于自己原则的人,不管原则是好是坏

耶鲁公开课 - 1871年后的法国课程节选

Christian in France expressed a different concern, saying: The big problem of the transgenic seeds is that they are the monopoly of big companies.

VOA: special.2010.05.18

This is a big problem. -Interesting.

这可是个大问题，-挺有趣。

普林斯顿公开课 - 人性课程节选

This is a big problem in poor countries.

VOA: special.2010.02.24

Taking the problem, recognizing that you know what, 8 even though this is a pretty big problem size 8 in this case and last time it was size 8 or in the case of the papers in size of a thousand roughly with the phonebook, I assume these are in a perfectly straight line they won't quite fit.

以这个问题为例，你们要认识到，在这种情况下，这是个比较大的问题，其大小是,上次它的大小也是8，但在纸片那个问题中,电话簿的规模大概是上千的，现在假设这些,杯子完全在同一条直线上，虽然并不十分符合这个条件。

哈佛公开课 - 计算机科学课程节选

Critics say one big problem is corruption.

VOA: special.2009.02.21

It's kind of unsettling because we like to know what things are, but at the same time it's not really a big problem because as long as we know about the fact that a certain notion of literature exists in certain communities we can begin to do very interesting work precisely with that idea.

可能会有点让人不安，因为我们总想知道事物的定义，但知不知道,实际上问题不大,只要我们知道在特定群体中对文学有特定的认识,我们就能在这种认识上做文章。

耶鲁公开课 - 文学理论导论课程节选

A big problem,however,is the cost.

VOA: special.2010.06.02

That's a big problem a lot, I think in group projects

我觉得这是很多团队项目当中的大问题，

怎么协调意见冲突 - SpeakingMax英语口语达人

A big problem,however,is cost.

VOA: special.2010.06.29

But there's a big confound, there's a big problem in studies of those kind of relationships.

但是有一个让人混淆的问题,存在于这种关系的研究中。

耶鲁公开课 - 心理学导论课程节选

"So it's still a big problem in the society. In my book,they are afraid of the father losing his green card.

VOA: standard.2010.07.22

Portion sizes, and we'll devote a class to this later on, have gone way up and that's a big problem, the amount of processing I mentioned.

食物份量直线上升,这是个问题,我们将专门用一堂课讲这个,即刚才提到的食品加工程度的问题

耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

"I think this is the big problem of the Abhisit government because his government still believes in trickle-down effect."

VOA: standard.2010.03.24

We want to solve a really big problem.

我们想解决一个非常大的难题。

斯坦福公开课 - Twitter之父Jack.Dorsey演讲：好奇和灵感的力量课程节选

"Illegal logging is such a big problem simply because of the size of it.

VOA: standard.2010.07.28

So I hope it's not a big problem.

我希望不是什么大问题。

Is it okay 实战 - SpeakingMax英语口语达人

But he says Ireland is not the last obstacle. He says another big problem is that the president of Czech Republic Vaclav Klaus has also not signed.

VOA: standard.2009.10.02

So if you're impure at home and just minding your own business, it's no big deal. It's only a problem if you decide you want to go to the sanctuary. So purity and impurity are states of qualification or disqualification for contact with sancta.

如果在家的时候不纯洁，一心只关注自己的事情，这倒不是什么大事，只有当你想去圣所的时候,才是个问题，因此纯洁和不纯洁只是表明了,你是否有资格接触圣所。

耶鲁公开课 - 旧约导论课程节选

The researchers say showers may not be big a problem for healthy people.

VOA: special.2009.10.13

How does this thing grow as I make the problem size big?

也就是说当问题规模变大的时候,算法计算的时间会怎样增长？

麻省理工公开课 - 计算机科学及编程导论课程节选

Big mosquitoes were a problem at the camp.

VOA: special.2009.01.24

Problem is, how big is that number?

因此我们也不用对？

麻省理工公开课 - 计算机科学及编程导论课程节选

The big problem life insurance had was people would buy it and they'd pay for several years and eventually they would think, well we didn't die, we're losing all this money, let's just cancel the insurance.

人寿保险的一个主要问题是,人们在购买了若干年保险后会突然觉得,我们并没有死,保费白花了,我们干脆把保险取消好了

耶鲁公开课 - 金融市场课程节选