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genome annotation

gene mutation 基因突变

  • Gene product annotation using GO continues to increase both in the number of total annotations and in species coverage.

    使用GO进行的基因产物注释总的注释数目物种覆盖继续增加

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  • Current gene annotation efforts focus on centralized curation resources, but it is increasingly clear that this approach does not scale with the rapid growth of the biomedical literature.

    当前基因注释努力集中集中式精选资源但是越来越清楚这种方式不能生物医学文献快速增长相称。

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  • Cut the neighboring sequence of SNPs and compare with the gene annotation database of NCBI to find their distribution among coding sequence, as well as the effects they have on amino acids coding.

    为了了解SNP编码基因影响,截取SNP位点两侧序列人类基因注释进行序列同源性比较了解SNP编码区域编码区域的分布情况

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  • DAVID is a Web-based application that provides a high-throughput and integrative gene functional annotation environment to systematically extract biological themes behind large gene lists.

    使用DAVID进行通量基因功能分析提供重要的见解,这些见解允许研究者在它们给定基因组研究中理解生物学主题

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  • Standard Affymetrix probe set annotation is gene-centered, i. e. probe set is precisely linked to gene, and probe set expression is interpreted as gene expression.

    标准探针注释是以基因中心,也就是探针特定的基因关联起来,而且探针表达谱最终会翻译基因表达谱。

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  • In this paper, drawbacks in the annotation of gene function currently used in genomics and some strategies beneficial to the annotation of gene function are discussed.

    本文综合讨论目前基因组基因功能注释存在问题解决这些问题策略方法

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  • Coupling structural and functional annotation across genomes in a comparative manner promotes more accurate annotation as well as an understanding of gene and genome evolution.

    一种比较方式进行基因组联合结构注释功能注释促进了更准确注释以及基因基因组进化的一个理解

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  • To find unknown protein-coding genes, annotation pipelines use a combination of ab initio gene prediction and similarity to experimentally confirmed genes or proteins.

    为了找出编码蛋白质基因注释流程结合了“从头开始基因预测方法已知基因相似性比较”这两种方法

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  • Promoter determines the positon of transcriptional start point and the frequency with which the gene is transcribed, so promoter recognition is important for genome annotation.

    启动子决定转录起始转录频率关键元件,因此启动子识别整个基因组功能的诠释具有重要作用。

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  • Structural annotation is the foundation of all genomics as without accurate gene models understanding gene function or evolution of genes across taxa can be impeded.

    结构注释所有基因组学基础因为没有准确基因模型分类群理解基因功能基因进化可能受阻碍

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  • These can be applied to many research problems, ranging from SNP selection for candidate gene screening, through cross-species evolutionary comparisons, to microarray annotation.

    这些能够用于多种研究问题通过物种进化比较SNP选择以进行候选基因筛选微阵列注释

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  • Structural annotation is dependent on sensitive, specific computational programs and deep experimental evidence to identify gene features within genomic DNA.

    结构注释依赖敏感的、特异计算程序深刻实验证据识别基因组DNA中的基因特征

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  • While at a micro level, genome annotation can help to describe the full complexity of gene regulation, variation, and transcript diversity.

    微观水平基因组注释能够帮助描述基因调控变异转录多样性完全复杂性

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  • While at a micro level, genome annotation can help to describe the full complexity of gene regulation, variation, and transcript diversity.

    微观水平基因组注释能够帮助描述基因调控变异转录多样性完全复杂性

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