Therefore to investigate the drug resistance mechanism of refractory epilepsy, and develop new strategies for treatment may have the deep influence in future.
因此研究难治性癫痫对抗癫痫药物产生耐药的原因，并谋求新的治疗措施，具有长远的意义。
ObjectiveTo establish and research the rat model of refractory epilepsy and investigate the rule of P-glycoprotein expression to make the mechanism of drug resistance clear.
目的建立大鼠难治性癫痫模型并观察其特点及研究多药物耐药蛋白P-糖蛋白表达规律，探讨癫痫耐药机制。
In this paper, the recent progresses about the multi-drug resistance in the treatment of intractable epilepsy were summarized.
本文对难治性癫痫近年来有关多药耐药现象进行综述。
Most patients with epilepsy drugs need lifelong medication, whether Western or Chinese medicine, can only control the disease and no cure, long-term side effects and drug resistance also.
癫痫患者服用药物多数患者需要终身服药，不管是西药还是中药，只能控制病情而不能根治，长期还产生副作用和抗药性。
Most patients with epilepsy drugs need lifelong medication, whether Western or Chinese medicine, can only control the disease and no cure, long-term side effects and drug resistance also.
癫痫患者服用药物多数患者需要终身服药，不管是西药还是中药，只能控制病情而不能根治，长期还产生副作用和抗药性。
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