The Times piece was somewhat based on the conclusions of a meta analysis by the well respected Cochrane Review that surveyed a number of salt studies and which also found no clear benefit from reducing salt.
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According to the meta-analysis, 2% of researchers questioned were willing to confess to this.
ECONOMIST: Scientists are not quite as honest as might be hoped
In a meta-analysis published in 2007, he found no evidence that games made their players violent.
The reason is that a meta-analysis of the degludec major trials showed a potential adverse CV signal.
FORBES: FDA Panel Backs New Diabetes Drug: Will CV Study Be Needed Before Approval?
This type of study, known as a meta-analysis, can highlight problems that no single study typically can.
"The authors themselves said the mortality trends shown in the meta-analysis could be due to chance, " says Wolfe.
It says that its own meta-analysis of 41 Celebrex studies containing 44, 000 patients found no excess heart risk.
The meta-analysis showed that people with allergies had a 24% reduced risk of developing head and neck cancers.
Additionally, a 2007 meta-analysis found a correlation between increased coffee consumption and lower risk of liver cancer.
The technique of pooling disparate clinical trials, called meta-analysis, has become the most powerful weapon of drug safety researchers.
If there is, of course, it will affect the result of the meta-analysis but not be detectable as bias.
The meta-analysis suggested that 14% of researchers in the underlying studies had seen their colleagues fabricate, falsify, alter or modify data.
ECONOMIST: Scientists are not quite as honest as might be hoped
According to a 2009 meta-analysis, the risk of type II diabetes goes down with each cup of coffee consumed daily.
Therefore, Dr. Nissen was invited to present and did present his meta-analysis to the committees as an FDA guest speaker.
FORBES: The FDA Responds To Steve Nissen's Criticism Of Upcoming Avandia Meeting
Validity of observer ratings of the Five-Factor Model of personality: A meta-analysis.
The Komen Web site cites a meta-analysis of the the two largest randomized controlled trials, one from China and one from Russia.
One is meta-analysis, in which the results of clinical trials are pooled together to try and tease out small effects of a treatment.
This meta-analysis, as it is known, strongly suggests that participation in a scared-straight programme substantially increases the likelihood of subsequent arrest among participants.
Zelnorm, a Novartis drug for painful bowel symptoms, was pulled from the market because of another meta-analysis that showed an increased risk of heart attacks.
Miller, Wampold, and Varhely, 2008 was a meta-analysis study designed to see if there are differences in efficacy among treatment models applied to children and youth.
That's according to a meta-analysis published in June in the American Heart Association's journal Circulation: Heart Failure, based on pooling the results of five studies.
But a meta-analysis of 23 studies by Karl Hanson of Canada's department of public safety found that psychological therapy was associated with a 43% drop in recidivism.
The company kept FDA apprised each step along the way as we worked to evaluate our own meta-analysis, along with the other available data, and take appropriate action.
FORBES: Glaxo Alleges Errors In Nissen's Critique Of FDA's Handling Of Avandia
It points out that it did share its meta-analysis with regulators both in the U.S. and in Europe--although it declines to comment on the timing of those meetings.
In the accepted hierarchy of evidence generation, the results of a randomized, controlled clinical trial usually take precedence over other forms of evidence such as meta-analysis and observational studies.
FORBES: Glaxo Alleges Errors In Nissen's Critique Of FDA's Handling Of Avandia
In a meta-analysis of the research literature on alcohol taxes and their impact on consumption, Wagenaar et al. found that a 10 percent increase in alcohol prices would result in a 5 percent reduction in drinking.
Back in January, my friend Bror Saxberg, chief learning officer of Kaplan, published an eye-popping blog about a meta-analysis that Kurt VanLehn published recently about nearly 100 well-constructed papers about computers used to tutor learners.
FORBES: How Machine-Based Tutoring Could Disrupt Human Tutors
The main point of the article is to explain why FDA is not taking action against Spiriva (generic name: tiotropium), a treatment for chronic obstructive pulmonary disorder sold by Boehringer Ingelheim and Pfizer, despite a meta-analysis that raised concerns.
We were aware that Dr. Nissen had performed an update to the meta-analysis of rosiglitazone trials that he published in 2007, and the FDA considered it important to provide Dr. Nissen an opportunity to present these new data to the advisory committees.
FORBES: The FDA Responds To Steve Nissen's Criticism Of Upcoming Avandia Meeting
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